The Schistosoma haematobium egg granuloma |
| |
Authors: | Amin I Kassis Kenneth S Warren Adel AF Mahmoud |
| |
Institution: | Division of Geographic Medicine, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, Ohio, USA |
| |
Abstract: | The etiology of the granulomatous response around Schistosoma haematobium eggs in mice was investigated. Eggs injected into the microvasculature of the lungs of mice evoked a granulomatous reaction which was demonstrated at 8 and 16 days. Prior exposure of mice to the eggs or to crude soluble egg antigens (SEA) resulted in significantly larger granulomas than in the unsensitized controls. The degree of sensitization was dependent both on the route of administration and the quantity of eggs. Furthermore, this phenomenon could be adoptively transferred with spleen cells from previously sensitized mice but not with serum. Mice sensitized with S. haematobium eggs and challenged by injection of SEA into their footpads developed both immediate and delayed swelling. Cross-sensitization between S. haematobium, S. mansoni and S. japonicum eggs was also studied in both the lung and footpad systems. |
| |
Keywords: | Address reprint requests to: Adel A F Mahmoud M D Ph D Division of Geographic Medicine University Hospitals Cleveland Ohio 44106 |
本文献已被 ScienceDirect 等数据库收录! |