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Possible mechanism of entrapment of neuraminidase-treated lymphocytes in the liver |
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| Authors: | Hubert Kolb Amelie Kriese Victoria Kolb-Bachofen Hans-Albert Kolb |
| Institution: | 1. Diabetes Research Institute, University of Düsseldorf, D 4000 Düsseldorf, W. Germany;2. Department of Biology, University of Konstanz, D 7750 Konstanz, W. Germany;3. Institute of Electron Microscopy, Department of Medicine, University of Düsseldorf, D 4000 Düsseldorf, W. Germany |
| Abstract: | Neuraminidase-treated rat lymphocytes adhere strongly to rat hepatocytes in vitro. Binding between cells is due to stereo-specific interactions between a mammalian hepatic membrane lectin and galactosyl residues which are exposed on the lymphocyte surface after removal of sialic acid residues. The hepatic galactose specific lectin may play a role in the trapping of recirculating desialylated lymphocytes in the liver. |
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