克罗烷二萜的昆虫拒食活性及构效关系研究

以饲料柱称重法测定25个克罗烷二萜新化合物对亚洲玉米螟Ostrinia furnacalis(Guenee)5龄幼虫的拒食活性，并进行构效关系分析。结果表明：立体效应对拒食活性意义 重大；C₉边链、C₁₈位的酯基对活性具有一定影响；C_{4处的螺环氧结构看来并非活性所必需。且在25μg/mL时选择法测定中，活性最高的化合物拒食率为57.9%，而500/μg/mL时非选择法测定中拒食率为43.2%。}

INSECT ANTIFEEDING ACTIVITIES AND THEIR RELATIONSHIP WITH STRUCTURES OF CLERODANE DITERPENOIDS

Twenty five clerodane diterpenoids were tested for antifeeding activities against fifth instar larvae of Ostrinia furnacalis (Guenee), and the structure-activity relationships were analyzed. Experimental results suggest that stereochemstry is importantfor antifeeding activity while the side chain at C₉ and acetyl group at C₁₈ exhibit certain effects, but a spiroepoxide structure at C₄ seems not important for the activity. The most potent antifeeding clerodane compound had an antifeeding ratio of 57.9% in choice test (250 μg/mL), and 43.2% in no-choice test (500 μg/mL).