Genetic mapping of anhidrotic ectodermal dysplasia: DXS159, a closely linked proximal marker |
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| Authors: | A Hanauer Y Alembik B Arveiler L Formiga S Gilgenkrantz J L Mandel |
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| Institution: | (1) Unité 184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CRNS, Institut de Chimie Biologique, Faculté de Médecine, F-67085 Strasbourg Cédex, France;(2) Centre de Transfusion Sanguine, F-54511 Vandoeuvre Les Nancy Cédex, France |
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| Abstract: | Summary Three families with anhidrotic ectodermal dysplasia (AED) have been studied by linkage analysis with seven polymorphic DNA markers from the Xp11-q21 region. Previously reported linkage to DXYS1 (Xq13-q21) has been confirmed (z( )=4.08 at =0.05) and we have also established linkage to another polymorphic locus, DXS159, located in Xq11-q12 (z()=4.28 at =0.05). Physical mapping places DSX159 proximal to the Xq12 breakpoint of an X autosome translocation found in a female with clinical signs of ectodermal dysplasia. Of all markers that have been used in linkage analysis of AED, DXS159 would appear the closest on the proximal side of the disease locus. |
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