Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness |
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Authors: | Takemiya Takako |
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Institution: | Medical Research Institute, Tokyo Women’s Medical University, Shinjuku, Tokyo 162-8666, Japan |
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Abstract: | This study examined the effect of prostaglandin E2 (PGE2) produced by microsomal prostaglandin E synthase-1 (mPGES-1) on circadian rhythm. Using wild-type mice (WT) and mPGES-1 knockout mice (mPGES-1−/−), I recorded and automatically analyzed the natural behavior of mice in home cages for 24 h and measured brain levels of PGE2. The switch to wakefulness was not smooth, and sleepiness and the total duration of sleep were significantly longer in the mPGES-1−/− mice. Moreover, the basal concentration of PGE2 was significantly lower in the mPGES-1−/− mice. These findings suggest that PGE2 produced by mPGES-1 regulates the onset of wakefulness and the maintenance of circadian rhythm. |
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Keywords: | Prostaglandin E2 Microsomal prostaglandin E synthase-1 (mPGES-1) mPGES-1 knockout mice Sleepiness |
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