Reduced activity of a sensory neuron during a sleep-like state in Caenorhabditis elegans |
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Authors: | Schwarz Juliane Lewandrowski Ines Bringmann Henrik |
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Affiliation: | Max Planck Institute for Biophysical Chemistry, Göttingen, Germany |
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Abstract: | Sleep-like states occur in the life of all animals carefully studied and are characterized by reduced behavioral and neural activity as well as reduced responsiveness to stimulation [1]. How is reduced responsiveness to stimulation generated? We used calcium imaging to investigate a sleep-like state in larvae of the nematode Caenorhabditis elegans. We found that overall spontaneous neural activity was reduced during the sleep-like state in many neurons, including the mechanosensory neuron ALM. Stimulus-evoked calcium transients and behavior were reduced in ALM during the sleep-like state. Thus, reduced activity of ALM may contribute to reduce responsiveness during a sleep-like state. |
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