Effects of fluoxetine on the activity of phagocytosis in stressed mice |
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Authors: | Freire-Garabal Manuel Núñez María J Riveiro Pilar Balboa José López Pablo Zamorano Braulio G Rodrigo Elena Rey-Méndez Manuel |
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Institution: | Neuroimmunology Laboratory, Department of Pharmacology, Schools of Medicine and Nursing, University of Santiago de Compostela, 15705, Santiago de Compostela, Spain. fffregar@usc.es |
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Abstract: | We studied the effects of 1, 2, 5, 10 and 20 mg/kg of fluoxetine on the activity of phagocytosis in mice subjected to a chronic auditory stressor. Both the in vitro and in vivo activity of phagocytosis, measured using the zymosan-particle uptake method and the carbon clearance test, respectively, were reduced after 2, 4, 8 and 16 days of stress exposure. A partial recovery on the in vivo activity of phagocytosis was found on day 16th. Daily treatment with fluoxetine partially reversed the adverse effects of stress in a dose-dependent manner on both parameters but did not significantly affect the activity of phagocytosis in unstressed mice. Significant differences appeared when fluoxetine was administered at 2 mg/kg. Maximum effect was reached at 5 mg/kg. |
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Keywords: | Fluoxetine Stress Phagocytosis Mice Macrophages Zymosan test Carbon clearance test |
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