Investigation of the importance of the C-2 and C-13 oxygen functions in the transformation of stemodin analogues by Rhizopus oryzae ATCC 11145 |
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Authors: | Martin Glenroy D A Reynolds William F Reese Paul B |
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Institution: | Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica. |
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Abstract: | Incubation of 2alpha,13(R)-dihydroxystemodane (3) with Rhizopus oryzae ATCC 11145 gave 2alpha,7beta,13(R)-trihydroxystemodane (11) while biotransformation of 13(R)-hydroxystemodan-2-one (5) yielded 6alpha,13(R)-dihydroxystemodan-2-one (12) and 7beta,13(R)-dihydroxystemodan-2-one (13). Bioconversion of 2beta,13(R)-dihydroxystemodane (7) with Rhizopus afforded 2beta,7,13(R)-trihydroxystemodane (14). The results complement data from our previous work and provide more information about the effect of functional groups of stemodane substrates on the site of hydroxylation. |
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Keywords: | Rhizopus oryzae ATCC 11145 Stemodia maritima Scrophulariaceae Stemodane Diterpene Biotransformation Hydroxylation Rhizopus arrhizus |
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