Mirex-induced liver enlargement in rats is dependent upon an intact pituitary-adrenalcortical axis |
| |
Authors: | MG Ervin James D Yarbrough |
| |
Institution: | Department of Biological Sciences Mississippi State University Mississippi State, MS 39762, USA |
| |
Abstract: | The effect of prior hypophysectomy upon mirex-induced liver hypertrophy in male Sprague-Dawley rats was examined. Mirex had no effect upon adrenal weight, liver weight, plasma glucose or plasma corticosterone in hypophysectomized rats. However, daily corticosterone supplements (20 mg/kg body weight, sc) given to mirex-treated hypophysectomized animals yielded a 52% increase in liver weight to body weight ratios over those observed in mirex-treated hypophysectomized animals not receiving supplement. In intact rats, both liver weight to body weight ratios and plasma ACTH were significantly increased over controls 2 days after mirex treatment. These results indicate that mirex-induced liver enlargement not only requires corticosterone, but that the response is dependent upon an intact pituitary-adrenalcortical axis. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|