Elevated plasma vasopressin in cardiomyopathic hamsters |
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Authors: | Alan F Sved John E Ottenweller Walter N Tapp Michael E Thompson Benjamin H Natelson |
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Institution: | 1. Research and Neurology Services, Veterans Administration Medical Center, East Orange, NJ 07019, USA;2. Department of Neurosciences, University of Medicine and Dentistry of New-Jersey Jersey Medical School, Newark, New Jersey 07103, USA |
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Abstract: | Hamsters of the BIO 14.6 strain characteristically develop cardiomyopathy as they age, and hamsters of this strain have overt signs of heart failure by 11 months of age. Plasma levels of the posterior pituitary hormone arginine-vasopressin (AVP) were found to be elevated (approximately 2-fold) in 11 month old BIO 14.6 hamsters, compared to age-matched hamsters of a control strain. AVP appeared inappropriately elevated in these animals, since they were neither hyperosmotic nor markedly hypotensive. The elevated levels of AVP observed in these animals appears to contribute to vasomotor tone, since intravenous adminstration of a specific antagonist of the vasoconstrictor action of AVP d(CH2)5Ome(TYR)AVP] elicited a fall in arterial pressure (9±2 mm Hg, n=6, p<0.05). The AVP antagonist had no effect on arterial pressure in hamsters of a control strain, and vehicle administration had no effect on arterial pressure in either strain. These data indicate that inappropriately elevated levels of AVP contribute to the cardiovascular state of myopathic hamsters. Since elevated plasma AVP has been noted in human congestive heart failure, these results suggest that AVP may contribute to the cardiovascular status during congestive heart failure. |
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Keywords: | Address correspondence to: Dr Alan Sved Neurology Service (127) VA Medical Center East Orange NJ 07019 |
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