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Oxygen-dependent reduction of a nitroxide free radical by electron paramagnetic resonance monitoring of circulating rat blood |
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| Authors: | Valentina Quaresima Cinzia L Ursini Giancaterino Gualtieri Antonello Sotgiu Marco Ferrari |
| Institution: | Department of Sciences and Biomedical Technologies, University L''Aquila, L''Aquila Italy |
| Abstract: | The effects of fraction of inspired oxygen (FiO2) on the reduction of a nitroxide free radical were studied by X-band electron paramagnetic resonance (EPR) monitoring of circulating rat blood. The decay half-life of the metabolism/elimination phase increased significantly by 24 ± 8% during hyperoxia and decreased significantly by 16 ± 4% during hypoxia. |
| Keywords: | EPR Nitroxide metabolism Oxygen Reduction rate in vivo EPR electron paramagnetic resonance PCA 2 2 5 5-tetramethylpyrrolidine-1-oxyl-3-carboxylic acid |
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