Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium |
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| Authors: | Jeffrey I. Penny F.Charles Campbell |
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| Affiliation: | Department of Surgery, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Scotland, UK |
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| Abstract: | Transport of the carcinogen benzo[a]pyrene in apical membrane vesicles (AMV) from normal human intestine, was investigated. Benzo[a]pyrene transport was found in AMV throughout the small intestine, but was greatest in colon. Evidence suggesting involvement of P-Glycoprotein (P-Gp), included (1) comparable transport of P-Gp substrate doxorubicin, (2) transport stimulation by ATP and (3) transport suppression by the P-Gp inhibitor, verapamil. |
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| Keywords: | Benzo[a]pyrene Intestine (human) Carcinogen Transport P-Glycoprotein |
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