Inhibition of glycolytic enzymes by endogenous aldehydes: a possible relation to diabetic neuropathies期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Inhibition of glycolytic enzymes by endogenous aldehydes: a possible relation to diabetic neuropathies

Authors:	Milos V Novotny Mark F Yancey Robert Stuart Donald Wiesler Richard G Peterson

Institution:	Department of Chemistry, Indiana University, Bloomington, IN 47405, USA

Abstract:	Endogenous saturated and unsaturated aldehydes were found in significant elevations in serum of diabetic humans and rats. These compounds, originating from the lipid peroxidation processes, are shown here to be potent inhibitors of the glycolytic enzymes, phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase. The inhibition process is non-competitive and progressive. The aldehyde mixture, when supplemented to the standard rat diet at $1100$ ratio, caused nerve damage that is reminiscent of diabetic polyneuropathies.

Keywords:	Neurotoxicity Endogenous aldehyde Glycolytic enzyme 2 5-HD 2 5-hexanedione ATP adenosine-5′-triphosphate DTT dithiothreitol GAPDH glyceraldehyde-3-phosphate dehydrogenase LC liquid chromatography LDH lactate dehydrogenase nicotine adeninedinucleotide (reduced and oxidized forms) PFK phosphofructokinase Tris tris(hydroxymethyl)aminomethane
本文献已被 ScienceDirect 等数据库收录！