FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
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| Authors: | Valentina V. Miroshnikova Ekaterina A. Polyakova Irina A. Pobozheva Aleksandra A. Panteleeva Natalia D. Razgildina Diana A. Kolodina Olga D. Belyaeva Olga A. Berkovich Sofya N. Pchelina Elena I. Baranova |
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| Affiliation: | 1.Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation. ;2.National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation. |
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| Abstract: | Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD. |
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| Keywords: | Coronary artery disease epicardial adipose tissue subcutaneous adipose tissue FABP4 omentin-1 |
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