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Polymorphisms of angiotensin II type 1 receptor gene and those of angiotensinogen point at culprit artery in ST-segment elevation myocardial infarction |
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| Authors: | Konopka Anna Szperl Małgorzata Piotrowski Walerian Stępińska Janina |
| Institution: | Institute of Cardiology, Warszawa, Poland. akonopka@ikard.pl |
| Abstract: | The aim of the study was to determine whether the presence of angiotensin II type 1 receptor 1166A/C gene polymorphism and two polymorphisms of angiotensinogen, namely Met235Thr and Thr174Met, pointed at the culprit artery in patients with ST-segment elevation myocardial infarction (STEMI). |
| Keywords: | STEMI ST-segment elevation myocardial infarction MI myocardial infarction AGTR1 angiotensin II type 1 receptor A adenine C cytosine AGT angiotensinogen Met methionine Thr threonine OR odds ratio CAD coronary artery disease RAS renin–angiotensin system ACE angiotensin-converting enzyme LAD left descending artery CRX circumflex artery RA right coronary artery pts patients PPCI primary percutaneous coronary intervention RFLP restriction fragment length polymorphism PCR polymerase chain reaction |
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