The effect of deuterium labeling on the genotoxicity of N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate |
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| Authors: | E V Sargent A R Kraynak R D Storer M O Bradley R M Perry |
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| Institution: | Corporate Safety and Industrial Hygiene, Merck and Co., Inc., Rahway, NJ 07065. |
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| Abstract: | Deuterated and non-deuterated N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate were evaluated for the ability to induce DNA single-strand breaks in rat hepatocytes as measured by alkaline elution. Non-deuterated nitrosodimethylamine induced twice the amount of DNA-strand breaks as the deuterated form. No evidence of a deuterium isotope effect was seen for the direct-acting alkylating agents epichlorohydrin and dimethyl sulfate. |
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