Chk1 activation and the nuclear/cytoplasmic ratio |
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Authors: | Pogoriler Jennifer Du Wei |
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Affiliation: | Ben May Institute for Cancer Research, Committee on Cancer Biology, University of Chicago, 924 East 57th Street, IL 60637 USA. |
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Abstract: | ATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of Developmental Cell, Conn et al. shed a novel light on the molecular mechanism of Chk1 activation and raise the possibility of a developmental checkpoint that regulates Chk1 in response to the nuclear/cytoplasmic ratio. |
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