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Endogenous homovanillic acid levels differ between rat and rabbit caudate,hippocampus, and cortical regions
Authors:Tomás A. Reader  Karen M. Dewar
Affiliation:(1) Centre de recherche en sciences neurologiques, Département de physiologie, Faculté de Médecine, Université de Montréal, H3C 3J7 Montréal, Québec, Canada;(2) Fonds de la Recherche en Santé du Québec, Canada
Abstract:Endogenous dopamine (DA) levels and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3MT) and homovanillic acid (HVA) were measured by high-performance liquid chromatography in the entorhinal-piriform (EnPi), cingulate (CIN), sensorimotor (SSM) and visual (VIS) cortices as well as is the caudate (CAU) and hippocampus (HIP) of Sprague-Dawley (SD) rats and New Zealand (NZ) rabbits. The DA, DOPAC and 3MT contents were similar in both species. The HVA levels however, although they followed DA distribution, were several-fold higher in NZ rabbits than in SD rats for all cortices, HIP and CAU. In addition, total metabolite contents and DA turnove (estimated from lsquoDA metabolite/DArsquo ratios) were significantly higher in NZ rabbits than in SD rats, suggesting an increased release and/or metabolism in the former species. The HVA/DA ratios were much higher for NZ rabbit regions than for SD rats, indicating an increased DA release in the former species since the DOPAC/DA ratios (index of intraneuronal degradation) were similar.Herbert H. Jasper Postdoctoral Fellow, Centre de recherche en sciences neurologiques.
Keywords:Dopamine  metabolites  rat  rabbit  caudate  hippocampus  cortex  turnover
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