Genetic Specificity of Stress-Induced Anemia in Rats |
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| Authors: | M C Datta H G AbdelRahman K K Srivastava G S Smith |
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| Institution: | 1. Department of Chemistry, Tuskegee University, Tuskegee, Alabama, 36088
2. Department of Pathobiology, Tuskegee University, Tuskegee, Alabama, 36088
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| Abstract: | There is a genetic difference in rat hemoglobin (Hb) β-chain structure, with alternate alleles, A and B, at a single locus. This study was designed to find out whether marrow sensitivity due to γ exposure and experimentally induced anemia in age-matched adult rats is entirely strain specific or is a combination of both strain and Hb genotype. Eight strains of inbred and outbred rats comprising AA and BB types were examined. The data indicate that there is a relationship between marrow sensitivity and Hb genotypes in response to erythropoietic stress caused by three techniques. |
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