Role of protein synthesis in the accumulation of ferritin mRNA during exposure of cells to iron. |
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| Authors: | E Mattia J den Blaauwen and J van Renswoude |
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| Institution: | E.C. Slater Institute for Biochemical Research, University of Amsterdam, The Netherlands. |
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| Abstract: | The iron-induced biosynthesis of ferritin is regulated at the translational level via multiple mechanism. A prolonged exposure of cells to iron leads to a marked increase in ferritin mRNA levels caused by stabilization of the message. Here we show that this stabilization requires the synthesis de novo of an iron-inducible protein factor. |
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