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A new class of glycogen phosphorylase inhibitors |
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| Authors: | Lu Zhijian Bohn Joann Bergeron Raynald Deng Qiaolin Ellsworth Kenneth P Geissler Wayne M Harris Georgianna McCann Peggy E McKeever Brian Myers Robert W Saperstein Richard Willoughby Christopher A Yao Jun Chapman Kevin |
| Institution: | Department of Basic Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. zhijian_lu@merck.com |
| Abstract: | A new class of diacid analogues that binds at the AMP site not only are very potent but have approximately 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed. |
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