| 尖吻蝮(Agkistrodon acutus)蛇毒凝血酶样成分的研究——Ⅲ.蛇毒凝血酶止血效应的研究 |
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| 引用本文： | 何丽芬,肖昌华,董馥明,杨连玺. 尖吻蝮(Agkistrodon acutus)蛇毒凝血酶样成分的研究——Ⅲ.蛇毒凝血酶止血效应的研究[J]. 动物学研究, 1990, 11(4): 331-335 |
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| 作者姓名： | 何丽芬 肖昌华 董馥明 杨连玺 |
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| 作者单位： | 中国科学院昆明动物研究所(何丽芬，肖昌华)，云南省个旧生物制药厂(董馥明)，中国科学院昆明动物研究所(杨连玺) |
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| 摘 要： | 将纯化得到的蛇毒凝血酶(TLE_3、TLE_4),经家兔体内实验表明,2—3凝血酶单位/kg体重剂量能显著地使家兔全血凝血时间缩短1/3—1/2。药后1小时即有促凝作用,以2—4小时凝血(止血)效应最强,12小时已消失。与Holleman, W. H.等自美洲矛头蝮蛇毒中得到的蛇毒凝血酶(Hemocoagulase)相似。经家兔及家犬实验性创伤止血实验表明,对创伤出血有止血作用。
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| 关 键 词： | 凝血酶样酶 蛇毒凝血酶 止血效应 止血药 |
STUDIES ON THE THROMBIN-LIKE PRINCIPLES OF Agkistrodon acutus VENOM III. STUDIES ON HEMOSTATIC EFFECT OF HEMOCOAGULASE |
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| He Lifeng Xiao Changhua Dong Fuming Yang Lianxi. STUDIES ON THE THROMBIN-LIKE PRINCIPLES OF Agkistrodon acutus VENOM III. STUDIES ON HEMOSTATIC EFFECT OF HEMOCOAGULASE[J]. Zoological Research, 1990, 11(4): 331-335 |
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| Authors: | He Lifeng Xiao Changhua Dong Fuming Yang Lianxi |
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| Abstract: | Thrombin-like enzymes (TLE3, TLE4) had been isolated and purified from the venom of Agkistrodon acutus. With 2- 3 NIH units/kg in vivo the result showed that the blood coagulation time of rabbits was shortened in 1/3-1/2. In vivo eyperiments (2NIH or 3NIH/kg) after 1 hr TLE began to show effect, after 2 - 4 hr the effect was most strong, after 12 hr there was no effect. The properties of TLE is similar to hemocoagulase from venom Bathrope jararaca. The experiments showed that TLE 3 and 4 of A. acutus can used as hemostatic agents. |
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| Keywords: | Thrombin-like enzyones (TLE) Hemocoagulase Hcmostasis Hemostatic drug |
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