Plant-based corosolic acid: Future anti-diabetic drug? |
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Authors: | Ganapathy Sivakumar Daniel R Vail Vipin Nair Fabricio Medina-Bolivar Jackson O Lay Jr |
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Institution: | 1. Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR, USA;2. Arkansas Statewide Mass Spectrometry Facility, University of Arkansas, Fayetteville, AR, USA |
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Abstract: | Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in the treatment of diabetes, but without induction of anti-insulin antibodies. Recently, corosolic acid from Lagerstroemia speciosa L. leaf extracts has been reported to act via an indirect mechanism (unlike insulin) in animal experiments. The insulin-complementary anti-diabetic therapeutic value observed in these Japanese preliminary clinical trials has led to renewed interest in the biosynthesis of this compound. So far, there has been no clear evidence for a corosolic acid biosynthetic pathway in plants. This article provides possible roles of corosolic acid and hypothetical information on the biosynthetic pathway in plants. |
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Keywords: | Anti-diabetic Banaba Corosolic acid Lagerstroemia speciosa Terpenoids |
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