Microarray Studies in Bacillus subtilis |
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| Authors: | Pınar Kocabaş Pınar Çalık Güzide Çalık Tunçer H. Özdamar Dr. |
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| Affiliation: | 1. Biochemical Reaction Engineering Laboratory, Chemical Engineering Department, Ankara University, 06100 Ankara, Turkey;2. Industrial Biotechnology and Metabolic Engineering Laboratory, Chemical Engineering Department, Middle East Technical University, 06531 Ankara, Turkey |
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| Abstract: | This review focuses on the construction of a global, comprehensive understanding of Bacillus subtilis through microarray studies. The microarray studies in B. subtilis were analysed based on the theme of the work, by mentioning the growth media, bioreactor operation conditions, RNA isolation method, number of data points analysed in exponential or stationary phases, compared genotypes, induction and repression ratios, investigated gene(s) and their positive and/or negative influences. Based on the theme and scope of the studies, the articles were reviewed under seven thematic sections, i.e., effects of gene deletion(s) or overexpression, effects of overexression of heterologous genes, comparison of global gene expression between aerobic and anaerobic respiration, effects of temperature change, effects of transported molecules, effects of limitations and stress conditions, and other microarray studies in B. subtilis. |
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