Nucleotide sequence analysis of Aleutian mink disease parvovirus shows that multiple virus types are present in infected mink. |
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| Authors: | E Gottschalck S Alexandersen A Cohn L A Poulsen M E Bloom and B Aasted |
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| Institution: | Department of Veterinary Microbiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg C, Denmark. |
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| Abstract: | Different isolates of Aleutian mink disease parvovirus (ADV) were cloned and nucleotide sequenced. Analysis of individual clones from two in vivo-derived isolates of high virulence indicated that more than one type of ADV DNA were present in each of these isolates. Analysis of several clones from two preparations of a cell culture-adapted isolate of low virulence showed the presence of only one type of ADV DNA. We also describe the nucleotide sequence from map units 44 to 88 of a new type of ADV DNA. The new type of ADV DNA is compared with the previously published ADV sequences, to which it shows 95% homology. These findings indicate that ADV, a single-stranded DNA virus, has a considerable degree of variability and that several virus types can be present simultaneously in an infected animal. |
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