The effects of interferon on epidermal growth factor action |
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| Authors: | S L Lin P O Ts'o M D Hollenberg |
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| Affiliation: | 1. Division of Biophysics, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205 USA;2. Division of Pharmacology and Experimental Therapeutics, The University of Calgary Faculty of Medicine, Calgary, Canada T2N 1N4 |
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| Abstract: | Epidermal growth factor-stimulated thymidine incorporation in human fibroblasts is inhibited more than 80% by human interferon, whereas the stimulation of α-aminoisobutyrate uptake is unaffected. Maximum inhibition of thymidine incorporation is observed after treatment of cells with interferon prior to the onset of DNA synthesis. However, even after the initiation of DNA synthesis, interferon rapidly blocks any further increase in thymidine incorporation. Despite these effects, interferon treatment causes no alterations in epidermal growth factor binding, receptor downregulation or receptor reappearance. |
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| Keywords: | To whom correspondence should be addressed. |
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