Sex differences in neuropeptide distribution in the rat brain |
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| Authors: | Rugarn O Hammar M Theodorsson A Theodorsson E Stenfors C |
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| Institution: | Division of Obstetrics and Gynecology, Faculty of Health Sciences, Link?ping University, Sweden. matha@kkl.us.lio.se |
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| Abstract: | We have investigated possible sex differences in the regional concentrations of neuropeptides in the rat brain. Immunoreactive neurotensin (NT), neurokinin A (NKA), galanin (GAL), calcitonin gene-related peptide (CGRP), substance P (SP) and neuropeptide Y (NPY) were measured by radioimmunoassay in frontal cortex, occipital cortex, hippocampus, striatum, hypothalamus and pituitary in male and female pre- and postpubertal rats. Sex differences were found for NPY (p < 0.001), NT (p < 0.01) and GAL (p < 0.05), in particular in hippocampus, striatum, hypothalamus and pituitary, but not for CGRP, SP and NKA. Results from analysis of neuropeptides in one sex may not be entirely applicable to the other. |
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