AMPK mediates autophagy during myocardial ischemia in vivo |
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| Authors: | Takagi Hiromitsu Matsui Yutaka Hirotani Shinichi Sakoda Hideyuki Asano Tomoichiro Sadoshima Junichi |
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| Affiliation: | Cardiovascular Research Institute, Department of Cell Biology and MolecularMedicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA. |
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| Abstract: | We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo. |
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