| 人凝血酶原复合物分离纯化工艺的研究进展 |
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| 引用本文： | 邱家山,徐琦,方为茂,钟本和. 人凝血酶原复合物分离纯化工艺的研究进展[J]. 生物技术通报, 2006, 0(2): 17-20,24 |
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| 作者姓名： | 邱家山 徐琦 方为茂 钟本和 |
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| 作者单位： | 四川大学化工学院,成都,610065 |
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| 摘 要： | 人凝血酶原复合物(PCC)为人血浆中微量蛋白组份,其浓缩制剂由凝血因子II、VII、IX、X组成,在临床上具有治疗乙型血友病等疾病的确切疗效。本文综述了近来PCC及FIX浓缩制剂分离纯化工艺的研究进展及结合蛋白新型分离纯化技术的发展情况,讨论了该产品制备新工艺的开发方向。
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| 关 键 词： | 人凝血酶原复合物 分离纯化 血浆蛋白 |
| 收稿时间： | 2005-11-17 |
| 修稿时间： | 2005-11-17 |
Advance in Fractionation and Purification for Human Prothrombin Complex Concentrates |
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| Qiu Jiashan,Xu Qi,Fang Weimao,Zhong Benhe. Advance in Fractionation and Purification for Human Prothrombin Complex Concentrates[J]. Biotechnology Bulletin, 2006, 0(2): 17-20,24 |
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| Authors: | Qiu Jiashan Xu Qi Fang Weimao Zhong Benhe |
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| Affiliation: | Chemical Engineering Institute,Sichuan University, Chengdu 610065 |
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| Abstract: | Prothrombin Complex Concentrates(PCC) are minim fraction in human plasma.It contains factor II,factor VII,factor IX,factor XI.PCC are currently licensed for the treatment of Hemophilia B and of the deficiencies of the Vitamin K dependent coagulation factor.This paper has resulted in the development of the fractionation and purification for PCC and highly purified FIX.The new preparation of PCC and FIX are presented by the development of new technology about proteins fractionation and purification. |
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| Keywords: | Prothrombin complex concentrate Fractionation and purification Plasma protein |
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