|
|||||
|
|
Synthesis and antiproliferative activity of a novel N-acyl derivative of doxorubicin] |
|
| Authors: | V M Shcherbakov V M Devichenski? E A Vorontsov S L Kuznetsov L N Kriukov |
| Institution: | Institute of Biological Medicine, Moscow, Russia. |
| Abstract: | Doxorubicin was acylated with estrone 3-hemisuccinate. The modified derivative exhibited high antiproliferative activity in vitro toward cell cultures of the MCF-7 human mammary adenocarcinoma and HepG2 human hepatoma. |
| Keywords: | |