| 自噬新蛋白Atg101的相关研究进展 |
| |
| 引用本文： | 马静远,杨颖,韩峻峰.自噬新蛋白Atg101的相关研究进展[J].中国细胞生物学学报,2020(3):507-511. |
| |
| 作者姓名： | 马静远 杨颖 韩峻峰 |
| |
| 作者单位： | 上海交通大学附属第六人民医院内分泌代谢科 |
| |
| 基金项目： | 国家自然科学基金(批准号:81471085、81670791)资助的课题。 |
| |
| 摘 要： | 自噬是真核细胞特有的生命现象,它控制着细胞内蛋白质和细胞器的降解,并在机体的生长发育和维持能量平衡中起重要的作用。目前在酵母中已被鉴定的自噬相关基因有40余种。Atg101是一种全新的自噬相关蛋白,近年来,其分子结构及功能逐步被阐明,其在疾病发展中的作用也引起了广泛关注。该综述总结了近年来Atg101在分子生物学和病理生理领域的相关研究进展。
|
| 关 键 词： | 自噬 Atg101 ULK1自噬起始复合体 |
Research Progress of New Autophagy-Related Protein Atg101 |
| |
| Authors: | MA Jingyuan YANG Ying HAN Junfeng |
| |
| Institution: | (Department of Endocrinology and Metabolism,Shanghai JiaoTong University Affiliated Sixth People's Hospital,Shanghai Institute for Diabetes,Shanghai Key Laboratory of Diabetes,Shanghai Clinical Medical Centre of Diabetes,Shanghai Key Clinical Centre of Metabolic Diseases,Shanghai 200233,China) |
| |
| Abstract: | Autophagy (macroautophagy) is a unique life phenomenon of eukaryotic cells.Autophagy not only controls the degradation of proteins and organelles in cells,but also plays pivotal roles in growth and maintain cellular homeostasis.From yeast genetic studies,more than 40 ATG genes have been identified up to now.Atg101 is a new autophagy-related protein which has been recently discovered.Currently,the molecular structure and function of Atg101 have been gradually elucidated,and its role in disease development has also been studied.This review summarizes recent research advances in the structure and function of Atg101. |
| |
| Keywords: | autophagy Atg101 ULK1 autophagy initiation complex |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
