Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels |
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Authors: | S. Hehl B. Neumcke |
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Affiliation: | (1) I. Physiologisches Institut, Universität des Saarlandes, W-6650 Homburg/Saar, Germany |
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Abstract: | Blockage of ATP-sensitive K+ channels by various drugs has been reported to exhibit a weak concentration dependence with Hill coefficients below unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the drug affinities of neighbouring channels. Results are presented for a dimeric and a tetrameric channel model and compared with published experimental data.Correspondence to: S. Hehl |
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Keywords: | Potassium channel Channel blockage Hill coefficient Negative cooperativity |
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