| Apoptin——一种特异性地促进肿瘤细胞凋亡的蛋白质 |
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| 引用本文： | 陶冶,张靖溥.Apoptin——一种特异性地促进肿瘤细胞凋亡的蛋白质[J].生物化学与生物物理进展,2001,28(5):631-634. |
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| 作者姓名： | 陶冶 张靖溥 |
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| 作者单位： | 中国科学院发育生物学研究所北京100080 |
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| 摘 要： | 鸡贫血病毒(CAV)的vp3基因编码的一种小蛋白质apoptin，可以通过独立于p53作用途径的、不被Bcl-2过量表达所抑制的方式，诱导肿瘤细胞或转化细胞凋亡,而对正常细胞不发挥作用.Apoptin的这些特征使其可能成为一种有效的抗肿瘤药物，apoptin诱导细胞凋亡的独特方式对于研究细胞转化机制和细胞凋亡途径也很有启发.
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| 关 键 词： | 鸡贫血病毒，apoptin，细胞凋亡，p53，Bcl-2 |
| 收稿时间： | 2000/10/13 0:00:00 |
| 修稿时间： | 1/4/2001 12:00:00 AM |
Apoptin:A Protein Which can Specifically Induce Apoptosis in Tumorigenic Cells |
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| TAO Ye and ZHANG Jing-Pu.Apoptin:A Protein Which can Specifically Induce Apoptosis in Tumorigenic Cells[J].Progress In Biochemistry and Biophysics,2001,28(5):631-634. |
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| Authors: | TAO Ye and ZHANG Jing-Pu |
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| Institution: | Institute of Developmental Biology, The Chinese Academy of Sciences , Beijing 100080, China;Institute of Developmental Biology, The Chinese Academy of Sciences , Beijing 100080, China |
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| Abstract: | Chicken anemia virus vp3 gene encodes a small protein-Apoptin. It can induce apoptosis in tumorgenic or transformed cells but not in normal cells through a way that is independent of p53 reaction and can not be suppressed by the excessive expression of Bcl 2. All these facts make apoptin a potential antitumor agent. The unique way of apoptin inducing apoptosis is also useful to the study of the mechanisms of cell transformation and pathways of apoptosis. |
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| Keywords: | chicken anemia virus apoptin P53 Bcl-2 |
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