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Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site. |
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| Authors: | E Vieira A Binggeli V Breu D Bur W Fischli R Güller G Hirth H P M?rki M Müller C Oefner M Scalone H Stadler M Wilhelm W Wostl |
| Affiliation: | Pharma Research Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
| Abstract: | The identification, synthesis and activity of a novel class of piperidine renin inhibitors is presented. The most active compounds show activities in the picomolar range and are among the most potent renin inhibitors ever identified. |
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