Neocarzinostatin: interaction between the antitumor-active chromophore and the carrier protein. |
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Authors: | H Takashima S Amiya Y Kobayashi |
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Affiliation: | Research Laboratories, Kuraray Co., Ltd., Okayama. |
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Abstract: | Conformational analysis of neocarzinostatin, an antibiotic protein with antitumor activity, in its holo-state in solution was carried out by NMR-spectroscopy. The results showed a beta-barrel structure for the carrier protein, in which the chromophore is tightly enwrapped and thus shielded from exposure to the solvent. The three-dimensional structure of this complex led to the proposal of a possible mechanism for the exposure or release of the active principle due to subtle environmental changes, e.g., in pH. |
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