Characterization of a plasma factor having opiate and immunoactivity like beta-endorphin. |
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| Authors: | W K Ho K Y Kwok S Lam |
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| Affiliation: | Department of Biochemistry The Chinese University of Hong Kong Shatin, New Territories Hong Kong |
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| Abstract: | A factor from human plasma having opiate-like activity was characterized in the present study. In addition to its ability to inhibit the binding of [3H]-methionine-enkephalin to opiate receptors, it also cross-reacted with two β-endorphin specific anti-sera. Compared with β-endorphin, the plasma factor had a shorter action on inhibiting the contraction of the guinea pig ileum. By gel-filtration chromatography, the size of this factor was intermediate between that of β-endorphin and methionine-enkephalin. |
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| Keywords: | β-LPH β-lipotropin human β-endorphin the segment of the β-endorphin molecule between residues x and y met-ENK methionine enkephalin leu-ENK leucine enkephalin |
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