Effect of dynamic channelling on the transient-state kinetics of coupled enzyme reactions. |
| |
Authors: | G Pettersson |
| |
Institution: | Avdelningen f?r Biokemi, Kemicentrum, Lunds Universitet, P.O. Box 124, S-221 00 Lund, Sweden. Gosta.Pettersson@biokem.lu.se |
| |
Abstract: | Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance. |
| |
Keywords: | |
|
|