Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats |
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| Authors: | Ruiqian Wan Ismayil Ahmet Martin Brown Aiwu Cheng Naomi Kamimura Mark Talan Mark P Mattson |
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| Institution: | 1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;2. School of Pharmacy, Sungkyunkwan University, Suwon, South Korea;3. Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA;4. Department of Physiology, Georgia Health Sciences University, Augusta, GA, USA;5. School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia;1. Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil;2. Post Graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil;3. Food Technology Laboratory, Department of Food Technology, Federal Institute of the Sertão de Pernambuco (IFPE/ Sertão), Petrolina, Pernambuco, Brazil;4. Psychopharmacology Laboratory, Department of Psychology, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil;5. Laboratory of Microbial Processes in Food, Department of Food Engineering, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil;6. Laboratory of Pathology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil;1. Department of Animal Sciences, School of Environmental & Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA;2. Nutritional Sciences Graduate Program, Rutgers, The State University of New Jersey, New Bunswick, NJ, USA;3. New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA |
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| Abstract: | It has been reported that dietary energy restriction, including intermittent fasting (IF), can protect heart and brain cells against injury and improve functional outcome in animal models of myocardial infarction (MI) and stroke. Here we report that IF improves glycemic control and protects the myocardium against ischemia-induced cell damage and inflammation in rats. Echocardiographic analysis of heart structural and functional variables revealed that IF attenuates the growth-related increase in posterior ventricular wall thickness, end systolic and diastolic volumes, and reduces the ejection fraction. The size of the ischemic infarct 24 h following permanent ligation of a coronary artery was significantly smaller, and markers of inflammation (infiltration of leukocytes in the area at risk and plasma IL-6 levels) were less, in IF rats compared to rats on the control diet. IF resulted in increased levels of circulating adiponectin prior to and after MI. Because recent studies have shown that adiponectin can protect the heart against ischemic injury, our findings suggest a potential role for adiponectin as a mediator of the cardioprotective effect of IF. |
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