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Targeting the PI3K signaling pathway in cancer
Authors:Kwok-Kin Wong  Jeffrey A Engelman  Lewis C Cantley
Affiliation:1. Department of Medicine, Harvard Medical School, Boston, MA 02115, United States;2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, United States;3. Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, MA 02115, United States;4. Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, United States;5. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, United States;6. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, United States;1. National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;2. Biometrics Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;3. Women’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;1. Centre de Recherches en Cancérologie de Toulouse (CRCT), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Toulouse III Paul Sabatier, Toulouse, France;2. Laboratoire d''Excellence LABEX TouCAN, Toulouse, France;1. Children’s Hospital Los Angeles, Department of Pediatrics and Pathology, Division of Hematology, Oncology and Bone Marrow Transplantation, Keck School of Medicine, University of Southern California, Los Angeles, California, United States;2. Department of Biochemistry and Molecular Biology, Keck School of Medicine of University of Southern California, Los Angeles, California, United States;3. Norris Comprehensive Cancer Research Center, University of Southern California, Los Angeles, California, United States;1. Department of Medical Oncology, Guy''s and St. Thomas’ NHS Foundation Trust, UK;2. Department of Research Oncology, Division of Cancer Studies, King''s College London, UK;1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK;2. Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK;3. Division of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
Abstract:
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