Exercise prior to fat ingestion lowers fasting and postprandial VLDL and decreases adipose tissue IL-6 and GIP receptor mRNA in hypertriacylglycerolemic men |
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| Authors: | Mark J. Dekker Terry E. Graham T.C. Ooi Lindsay E. Robinson |
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| Affiliation: | 1. Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland;2. LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland;3. Department of Biological and Environmental Sciences, University of Jyväskylä, Jyväskylä, Finland;4. Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;1. Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain;2. HIV and Associated Metabolic Alterations Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR), Logroño, Spain;3. Faculty of Health and Physical Activity Science, University SEK, Santiago, Chile;4. INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France;5. University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, France;6. Department of Histology and Pathology, University of Navarra, Pamplona, Spain;7. Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France;8. Center for Nutrition Research, University of Navarra, Pamplona, Spain;9. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain |
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| Abstract: | Fasting and postprandial triacylglycerol (TAG) concentrations are risk factors for cardiovascular disease. This study evaluated whether interleukin-6 (IL-6) and incretin hormones [gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) (active)] were associated with fasting and postprandial TAG in response to an oral lipid load, including very-low-density lipoprotein (VLDL) and chylomicron (CM) TAG, following one bout of exercise in nine men (age, 59±2 years; body mass index, 34±2 kg/m2; waist circumference, 113±3 cm) with high fasting TAG (2.9±0.2 mmol/L). Subjects completed two oral fat tolerance tests (OFTTs), randomized 1 week apart, that consisted of 1g fat/kg body weight emulsified lipids in the absence of carbohydrate and protein. Approximately 16 h prior to one OFTT, subjects completed 60 min of treadmill walking (estimated 55% VO2 peak; heart rate, 122±4 beats/min). No exercise was performed on the day before the other OFTT. Fasted (0 h) and postprandial (1, 2, 3, 4, 5 and 6 h) blood samples were taken for analysis of TAG, IL-6 and incretins. Subcutaneous adipose tissue biopsies were taken at 0 and 6 h after OFTT ingestion for IL-6 and GIP receptor (GIPr) mRNA quantification. Exercise lowered fasting and postprandial TAG (P<.05) and VLDL TAG (P<.05), while postprandial CM TAG were similar in both OFTT trials (P>.05). Fasting and postprandial plasma IL-6, GIP and GLP-1 did not differ between rest and exercise OFTT trials (P>.05). Exercise reduced IL-6 and GIPr mRNA (P<.05) in adipose tissue. Our results suggest that the reduction in VLDL TAG following an acute bout of exercise is not associated with circulating IL-6 or incretin concentrations, despite reductions in the adipose tissue expression of IL-6 and GIPr. |
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