Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides |
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| Authors: | Natalia A Crivello Sherley L Casseus James W Peterson Donald E Smith Sarah L Booth |
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| Institution: | 1. Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging (JM USDA HNRCA) at Tufts University, Boston, MA 02111, USA;2. Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University;3. Vitamin K Laboratory, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA;4. Comparative Biology Unit, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA;1. Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA;2. Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN;3. Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, CA;4. Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA;1. Missouri School of Dentistry and Oral Health, A.T. Still University, 800 West Jefferson St., Kirksville, Missouri 63501, USA;2. Research Support, A.T. Still University, 5835 E. Still Circle Dr., Mesa, Arizona 85206, USA;1. Department of Anesthetics, Chang Gung Memorial Hospital at Linkuo and Chang Gung University, Kwei-San, Tao-Yuan, Taiwan;2. Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan;3. Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan;4. Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan;1. School of Psychology, Queen’s University Belfast, United Kingdom;2. Department of Experimental Psychology, University of Bristol, United Kingdom;1. Department of Anatomy, National University of Singapore, Singapore 119260, Singapore;2. Neurobiology and Ageing Research Programme, National University of Singapore, Singapore 119260, Singapore;3. Department of Biochemistry, College of Science, King Saud University, Riyadh 11495, Saudi Arabia;4. Department of Pharmacy, College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea |
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| Abstract: | Dysregulation of myelin sulfatides is a risk factor for cognitive decline with age. Vitamin K is present in high concentrations in the brain and has been implicated in the regulation of sulfatide metabolism. Our objective was to investigate the age-related interrelation between dietary vitamin K and sulfatides in myelin fractions isolated from the brain regions of Fischer 344 male rats fed one of two dietary forms of vitamin K: phylloquinone or its hydrogenated form, 2′,3′-dihydrophylloquinone (dK), for 28 days. Both dietary forms of vitamin K were converted to menaquinone-4 (MK-4) in the brain. The efficiency of dietary dK conversion to MK-4 compared to dietary phylloquinone was lower in the striatum and cortex, and was similar to that in the hippocampus. There were significant positive correlations between sulfatides and MK-4 in the hippocampus (phylloquinone-supplemented diet, 12 and 24 months; dK-supplemented diet, 12 months) and cortex (phylloquinone-supplemented diet, 12 and 24 months). No significant correlations were observed in the striatum. Furthermore, sulfatides in the hippocampus were significantly positively correlated with MK-4 in serum. This is the first attempt to establish and characterize a novel animal model that exploits the inability of dietary dK to convert to brain MK-4 to study the dietary effects of vitamin K on brain sulfatide in brain regions controlling motor and cognitive functions. Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure and behavior functions. |
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