Correspondence of the monocyte antigen HMA-1 to the non-HLA antigen 9a |
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Authors: | Martine J Jager Frans H J Claas Marian Witvliet Jon J van Rood |
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Institution: | (1) Department of Immunohaematology and Blood Bank, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands |
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Abstract: | Monocyte-specific antibodies are detrimental to bone marrow and renal transplantation. By using human antimonocyte sera we were able to identify two monocyte-specific antigens, human monocyte antigen 1 and 2 (HMA-1 and HMA-2). The presence of HMA-1 and HMA-2 was compared with the presence of several non-HLA antigens. In panel and inhibition studies, HMA-1 corresponded to the previously described non-HLA granulocyte antigen 9a. Absorption studies showed that HMA-1 and 9a were both present on granulocytes and monocytes. The clinical relevance of these antigens is discussed. |
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