CDH1 promoter polymorphism and stomach cancer susceptibility |
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Authors: | Yi-Ling Li Zhong Tian Jian-Bing Zhang Bao-Yu Fu |
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Institution: | (1) Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China;(2) Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China;(3) Cancer Research Institute, Nantong University, Nantong, China |
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Abstract: | The relationship of stomach cancer susceptibility and the presence of E-cadherin (CDH1) promoter −160 C/A polymorphism had been reported with conflicting results. To further explore the association of this polymorphism
with stomach cancer susceptibility, we performed an extensive search of relevant studies and carried out a meta-analysis to
obtain a more precise estimate. A total of 16 studies including 2,611 cases and 3,788 controls were involved in this meta-analysis.
When all studies involved, the meta-analysis results suggest no statistically significant association between CDH1 −160 C/A polymorphism and stomach cancer risk (CA vs. CC: OR = 1.01, 95% CI: 0.85–1.19; AA vs. CC: OR = 1.05, 95% CI: 0.75–1.46;
dominant model: OR = 1.02, 95% CI: 0.86–1.20; recessive model: OR = 1.04, 95% CI: 0.76–1.41). When subgroup analyses were
performed by ethnicity, the A-allele carriers conferred a decreased stomach cancer risk in Asians (AA vs. CC: OR = 0.67, 95%
CI: 0.47–0.96; dominant model: OR = 0.85, 95% CI: 0.72–0.99), but no statistically significant association was found in Caucasians.
In conclusion, this meta-analysis suggests that CDH1 −160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians. |
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