Protein dynamics from solution NMR |
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Authors: | James G Kempf J Patrick Loria |
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Institution: | (1) Department of Chemistry, Yale University, P.O. Box 208107, 06520 New Haven, CT |
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Abstract: | Solution nuclear magnetic resonance (NMR) spectroscopy is unique in its ability to elucidate the details of atomic-level structural
and dynamical properties of biological macromolecules under native-like conditions. Recent advances in NMR techniques and
protein sample preparation now allow comprehensive investigation of protein dynamics over timescales ranging 14 orders of
magnitude at nearly every atomic site. Thus, solution NMR is poised to reveal aspects of the physico-chemical properties that
govern the ensemble distribution of protein conformers and the dynamics of their interconversion. We review these advances
as well as their recent application to the study of proteins. |
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Keywords: | NMR spectroscopy protein dynamics chemical exchange spin relaxation |
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