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Regulation of AMPA Receptor Activity, Synaptic Targeting and Recycling: Role in Synaptic Plasticity
Authors:André R Gomes  Susana S Correia  Ana Luísa Carvalho  Carlos B Duarte
Institution:(1) Center for Neuroscience and Cell Biology, University of Coimbra, Portugal;(2) Department of Zoology, University of Coimbra, Portugal;(3) Department of Biochemistry, University of Coimbra, Coimbra, Portugal
Abstract:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localization to defined postsynaptic sites. This review focuses on recent advances in understanding the dynamic regulation of AMPA receptors, on a short- and long-term basis, and its implications in synaptic plasticity.
Keywords:Glutamate receptors  AMPA receptors  synaptic plasticity  protein phosphorylation  endocytosis  synaptic targeting
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