Evening alcohol suppresses salivary melatonin in young adults |
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Authors: | Rupp Tracy L Acebo Christine Carskadon Mary A |
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Institution: |
a E.P. Bradley Sleep and Chronobiology Laboratory, Providence, Rhode Island, USA
b The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
c Brown University Department of Psychology, Providence, Rhode Island, USA |
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Abstract: | The study objective was to determine the acute effects of a moderate evening dose of alcohol on salivary melatonin levels in humans with stable prior sleep-wake histories and in a controlled environment. Twenty-nine adults (nine males) ages 21 to 25 (M=22.6, SD=1.2) yrs adhered to a 10-day at-home stabilized sleep schedule followed by three in-lab adaptation, placebo, and alcohol (order counterbalanced) study nights. Alcohol (vodka: 0.54 g/kg for men and 0.49 g/kg for women) or placebo beverage was consumed over 30 min, ending 1 h before stabilized bedtime. At 140 and 190 min after alcohol administration, melatonin level was reduced by 15% and 19%, respectively, in comparison to placebo. The findings indicate that a moderate dose of alcohol in the evening suppressed melatonin in young adults. |
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Keywords: | Alcohol Melatonin suppression Dim light |
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