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| 人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌易感性的相关性 | |
| 引用本文： | Zhang XB,Zhao ZH,Chen HY,Wang JC,Qian J,Yang YJ,Wei QY,Huang J,Lu DR. 人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌易感性的相关性[J]. 遗传, 2011, 33(8): 886-894. DOI: 10.3724/SP.J.1005.2011.00886 |
| 作者姓名： | Zhang XB Zhao ZH Chen HY Wang JC Qian J Yang YJ Wei QY Huang J Lu DR |
| 作者单位： | 1. 复旦大学生命科学学院遗传工程国家重点实验室,上海,200433 2. 美国德州大学M.D.Anderson癌症中心流行病学系,休斯顿 TX 77030-3721 3. 上海交通大学基础医学院生物化学与分子细胞生物学系,上海,200025 |
| 基金项目： | 上海市科委重点项目(编号:09JC1402200); 上海市国际合作项目(编号:10410709100); 上海市重点学科建设项目(编号:B111)资助 |
| 摘 要： | 为探讨人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌遗传易感性之间的关系,文章采用病例-对照研究,对784例肺癌患者和782例性别、年龄、籍贯频数与之相匹配的健康对照中该区域6个标签SNP位点进行基因分型,并统计分析其基因型频率分布与肺癌易感性的关系,以及吸烟在其中的影响。结果发现rs16891561位点TT基因型在60岁以上人群(校正OR=0.42,95%CI=0.20-0.88;P=0.022)、女性人群(校正OR=0.34,95%CI=0.13-0.87;P=0.025)、非吸烟人群中(校正OR=0.32,95%CI=0.13-0.79;P=0.013)对肺癌发生具有保护效应;rs4236926位点TT基因型在60岁以上人群(校正OR=0.48,95%CI=0.23-0.99;P=0.048)、非吸烟人群(校正OR=0.32,95%CI=0.13-0.80;P=0.014)中对肺癌发生具有保护效应,这两种保护效应主要是与腺癌相关。对这两个位点进行累积效应分析发现,含有3~4个变异等位基因型的非吸烟者罹患肺癌的风险显著降低(校正OR=0.29,95%CI=0.11-0.71;P=0.007),并且,含有3~4个变异等位基因型的个体累计吸烟量("包-年"平均数=13.2)与其他个体相比显著降低。由此可见人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌易感性和吸烟行为相关。 |
| 关 键 词： | 8p11 CHRNB3 CHRNA6 单核苷酸多态性 肺癌易感性 |
Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population |
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| Zhang Xiao-Bo,Zhao Zhen-Hong,Chen Hong-Yan,Wang Jiu-Cun,Qian Ji,Yang Ya-Jun,Wei Qing-Yi,Huang Jian,Lu Da-Ru. Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population[J]. Hereditas, 2011, 33(8): 886-894. DOI: 10.3724/SP.J.1005.2011.00886 | |
| Authors: | Zhang Xiao-Bo Zhao Zhen-Hong Chen Hong-Yan Wang Jiu-Cun Qian Ji Yang Ya-Jun Wei Qing-Yi Huang Jian Lu Da-Ru |
| Affiliation: | ZHANG Xiao-Bo1,ZHAO Zhen-Hong1,CHEN Hong-Yan1,WANG Jiu-Cun1,QIAN Ji1,YANG Ya-Jun1,WEI Qing-Yi2,HUANG Jian3,LU Da-Ru1 1.State key laboratory of Genetic Engineering,The Institute of Genetics,School of Life Sciences,Fudan University,Shanghai 200433,China,2.Department of Epidemiology,The University of Texas M.D.Anderson Cancer Center,Houston,Texas,TX 77030-3721,USA,3.Department of Biochemistry and Molecular Cell Biology,Basic Medical College,Shanghai Jiaotong University,Shanghai 200025 |
| Abstract: | To investigate the association between chromosome 8p11(CHRNB3-CHRNA6) polymorphisms and lung cancer susceptibility in Chinese Han population,we genotyped 6 tag SNPs variants of this region among 784 patients with lung cancer and 782 age-and sex-matched cancer-free control participants to screen for any risk-associated SNPs.The results revealed that rs16891561 TT genotype had a protective effect against lung cancer in people over 60 years old(adjusted OR=0.42,95% CI=0.20-0.88;P=0.022),female groups(adjusted ... |
| Keywords: | 8p11 CHRNB3 CHRNA6 single nucleotide polymorphism lung cancer susceptibility |
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