Robust regression for periodicity detection in non-uniformly sampled time-course gene expression data |
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| Authors: | Miika Ahdesmäki Harri Lähdesmäki Andrew Gracey llya Shmulevich Olli Yli-Harja |
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| Institution: | (1) Institute of Signal Processing, Tampere University of Technology, P.O.Box 553, 33101 Tampere, Finland;(2) Institute for Systems Biology, WA 98103 Seattle, USA;(3) Marine Environmental Biology, University of Southern California, CA 90089 Los Angeles, USA |
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| Abstract: | Background In practice many biological time series measurements, including gene microarrays, are conducted at time points that seem to
be interesting in the biologist's opinion and not necessarily at fixed time intervals. In many circumstances we are interested
in finding targets that are expressed periodically. To tackle the problems of uneven sampling and unknown type of noise in
periodicity detection, we propose to use robust regression. |
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