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Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains |
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| Authors: | Gemma Sandra Kukreja Gagan Fattorusso Caterina Persico Marco Romano Maria P Altarelli Maria Savini Luisa Campiani Giuseppe Fattorusso Ernesto Basilico Nicoletta Taramelli Donatella Yardley Vanessa Butini Stefania |
| Institution: | Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy. |
| Abstract: | A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs. |
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