The influence of cytochalasin B on the response of adrenal tumor cells to ACTH and cyclic AMP. |
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| Authors: | J J Mrotek P F Hall |
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| Institution: | Department of Physiology, California College of Medicine, University of California, Irvine, California 92664 USA |
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| Abstract: | Cytochalasin B inhibits increase in steroid synthesis by mouse adrenal tumor cells (Y-1), produced either by ACTH or cyclic AMP. Basal levels of steroid synthesis are not decreased and the inhibitor acts by decreasing the response of the side-chain cleavage step (cholesterol → pregnenolone) to ACTH. Inhibition is reversible and is seen in medium without glucose. These observations suggest that microfilaments may play a role in the response of adrenal cells to ACTH. |
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